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Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy
Abnormally swollen regions of axons and dendrites (neurites) filled mainly with autophagy-related organelles represent the highly characteristic and widespread form of “neuritic dystrophy” in Alzheimer disease (AD), which implies dysfunction of autophagy and axonal transport. In this punctum, we dis...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3327621/ https://ncbi.nlm.nih.gov/pubmed/22024748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.12.17956 |
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