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Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

In the hallmark neuritic dystrophy of Alzheimer's disease (AD), autophagic vacuoles containing incompletely digested proteins selectively accumulate in focal axonal swellings, reflecting defects in both axonal transport and autophagy. Here, we investigated the possibility that impaired lysosoma...

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Detalhes bibliográficos
Main Authors: Lee, Sooyeon, Sato, Yutaka, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351137/
https://ncbi.nlm.nih.gov/pubmed/21613495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6412-10.2011
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