Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here we show that macroautophagy requires the Alzheimer's disease (AD) - related protein, presenilin-1 (PS1). In PS1-null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substra...

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Detalhes bibliográficos
Main Authors: Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S., Peterhoff, Corrinne M., Wolfe, Devin M., Martinez-Vicente, Marta, Massey, Ashish C., Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Sisodia, Sangram S., Cuervo, Ana Maria, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647462/
https://ncbi.nlm.nih.gov/pubmed/20541250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.05.008
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