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Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification

Autophagy is a lysosomal degradative process to recycle cellular waste and eliminate potentially toxic damaged organelles and protein aggregates. The important cytoprotective functions of autophagy are evidenced by the diverse pathogenic consequences that may stem from autophagy dysregulation in a g...

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Detalhes bibliográficos
Main Authors: Wolfe, Devin M., Lee, Ju-hyun, Kumar, Asok, Lee, Sooyeon, Orenstein, Samantha J., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694736/
https://ncbi.nlm.nih.gov/pubmed/23773064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.12169
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