Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

Increased activity of calpains is implicated in synaptic dysfunction and neurodegeneration in Alzheimer's disease (AD). The molecular mechanisms responsible for increased calpain activity in AD are not known. Here, we demonstrate that disease progression is propelled by a marked depletion of th...

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Detalhes bibliográficos
Main Authors: Rao, Mala V., Mohan, Panaiyur S., Peterhoff, Corrinne M., Yang, Dun-Sheng, Schmidt, Stephen D., Stavrides, Philip H., Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A., Cataldo, Anne M., Haroutunian, Vahram, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819018/
https://ncbi.nlm.nih.gov/pubmed/19020018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4119-08.2008
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