Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau species with enhanced neurotoxicity, although the generative mechanisms and the implications for disease therapy are not well understood. Her...

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Main Authors: Rao, Mala V., McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H., Ohno, Masuo, Hutton, Michael, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087203/
https://ncbi.nlm.nih.gov/pubmed/25009256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1132-14.2014
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