Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

Oxidative and nitrative injury is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down syndrome (DS), but no direct evidence links this type of injury to the formation of neurofibrillary tau lesions. To address this, we generated a monoclonal antibody (mAb), n847, which recognizes nit...

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Autors principals: Horiguchi, Takashi, Uryu, Kunihiro, Giasson, Benoit I., Ischiropoulos, Harry, LightFoot, Richard, Bellmann, Christine, Richter-Landsberg, Christiane, Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2003
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868254/
https://ncbi.nlm.nih.gov/pubmed/12937143
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