Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

Oxidative and nitrative injury is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down syndrome (DS), but no direct evidence links this type of injury to the formation of neurofibrillary tau lesions. To address this, we generated a monoclonal antibody (mAb), n847, which recognizes nit...

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Main Authors: Horiguchi, Takashi, Uryu, Kunihiro, Giasson, Benoit I., Ischiropoulos, Harry, LightFoot, Richard, Bellmann, Christine, Richter-Landsberg, Christiane, Lee, Virginia M.-Y., Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868254/
https://ncbi.nlm.nih.gov/pubmed/12937143
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