Overexpression of Wild-Type Murine Tau Results in Progressive Tauopathy and Neurodegeneration

Here, we describe the generation and characterization of a novel tau transgenic mouse model (mTau) that overexpresses wild-type murine tau protein by twofold compared with endogenous levels. Transgenic tau expression was driven by a BAC transgene containing the entire wild-type mouse tau locus, incl...

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Autors principals: Adams, Stephanie J., Crook, Richard J.P., DeTure, Michael, Randle, Suzanne J., Innes, Amy E., Yu, Xin Z., Lin, Wen-Lang, Dugger, Brittany N., McBride, Melinda, Hutton, Mike, Dickson, Dennis W., McGowan, Eileen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751556/
https://ncbi.nlm.nih.gov/pubmed/19717642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090462
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