Pharmacogenomics in pediatric leukemia

Por Paugh, Steven W., Stocco, Gabriele, Evans, William E.
Publicado em 2010

“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

Por TAKABE, KAZUAKI, PAUGH, STEVEN W., MILSTIEN, SHELDON, SPIEGEL, SARAH
Publicado em 2008

Mathematical Modelling of Folate Metabolism

Por Panetta, John C., Paugh, Steven W., Evans, William E.
Publicado em 2013

Inflammasome-mediated glucocorticoid resistance: The receptor rheostat

Por Paugh, Steven W., Bonten, Erik J., Evans, William E.
Publicado no Mol Cell Oncol (2015)

A Guide to the Current Web-Based Resources in Pharmacogenomics

Por Glubb, Dylan M., Paugh, Steven W., van Schaik, Ron H.N., Innocenti, Federico
Publicado em 2013

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

Por Gude, David R., Alvarez, Sergio E., Paugh, Steven W., Mitra, Poulami, Yu, JiaDe, Griffiths, Rachael, Barbour, Suzanne E., Milstien, Sheldon, Spiegel, Sarah
Publicado em 2008

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells

Por Paugh, Barbara S., Paugh, Steven W., Bryan, Lauren, Kapitonov, Dmitri, Wilczynska, Katarzyna M., Gopalan, Sunita M., Rokita, Hanna, Milstien, Sheldon, Spiegel, Sarah, Kordula, Tomasz
Publicado em 2007

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

Por Paugh, Steven W., Paugh, Barbara S., Rahmani, Mohamed, Kapitonov, Dmitri, Almenara, Jorge A., Kordula, Tomasz, Milstien, Sheldon, Adams, Jeffrey K., Zipkin, Robert E., Grant, Steven, Spiegel, Sarah
Publicado em 2008

A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity

Por Chen, Shih-Hsiang, Yang, Wenjian, Fan, Yiping, Stocco, Gabriele, Crews, Kristine R., Yang, Jun J., Paugh, Steven W., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Publicado em 2010

Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells

Por Paugh, Barbara S., Bryan, Lauren, Paugh, Steven W., Wilczynska, Katarzyna M., Alvarez, Silvina M., Singh, Sandeep K., Kapitonov, Dmitri, Rokita, Hanna, Wright, Sarah, Griswold-Prenner, Irene, Milstien, Sheldon, Spiegel, Sarah, Kordula, Tomasz
Publicado em 2009

The SWI/SNF Chromatin-Remodeling Complex and Glucocorticoid Resistance in Acute Lymphoblastic Leukemia

Por Pottier, Nicolas, Yang, Wenjian, Assem, Mahfoud, Panetta, John C., Pei, Deqing, Paugh, Steven W., Cheng, Cheng, Den Boer, Monique L., Relling, Mary V., Pieters, Rob, Evans, William E., Cheok, Meyling H.
Publicado em 2008

A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia

Por Bainer, Russell O, Trendowski, Matthew R, Cheng, Cheng, Pei, Deqing, Yang, Wenjian, Paugh, Steven W, Goss, Kathleen H, Skol, Andrew D, Pavlidis, Paul, Pui, Ching-Hon, Gilliam, T Conrad, Evans, William E, Onel, Kenan
Publicado no Cancer Manag Res (2017)

Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

Por Jones, Courtney L., Bhatla, Teena, Blum, Roy, Wang, Jinhua, Paugh, Steven W., Wen, Xin, Bourgeois, Wallace, Bitterman, Danielle S., Raetz, Elizabeth A., Morrison, Debra J., Teachey, David T., Evans, William E., Garabedian, Michael J., Carroll, William L.
Publicado em 2014

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia

Por Ramsey, Laura B., Janke, Laura J., Payton, Monique A., Cai, Xiangjun, Paugh, Steven W., Karol, Seth E., Kamdem, Landry Kamdem, Cheng, Cheng, Williams, Richard T., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Publicado no PLoS One (2015)

Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia

Por Drenberg, Christina D., Paugh, Steven W., Pounds, Stanley B., Shi, Lei, Orwick, Shelley J., Li, Lie, Hu, Shuiying, Gibson, Alice A., Ribeiro, Raul C., Rubnitz, Jeffrey E., Evans, William E., Sparreboom, Alex, Baker, Sharyn D.
Publicado no Clin Pharmacol Ther (2016)

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

Por Stocco, Gabriele, Yang, Wenjian, Crews, Kristine R., Thierfelder, William E., Decorti, Giuliana, Londero, Margherita, Franca, Raffaella, Rabusin, Marco, Valsecchi, Maria Grazia, Pei, Deqing, Cheng, Cheng, Paugh, Steven W., Ramsey, Laura B., Diouf, Barthelemy, McCorkle, Joseph Robert, Jones, Terreia S., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Publicado em 2012

MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression

Por Paugh, Steven W., Coss, David R., Bao, Ju, Laudermilk, Lucas T., Grace, Christy R., Ferreira, Antonio M., Waddell, M. Brett, Ridout, Granger, Naeve, Deanna, Leuze, Michael, LoCascio, Philip F., Panetta, John C., Wilkinson, Mark R., Pui, Ching-Hon, Naeve, Clayton W., Uberbacher, Edward C., Bonten, Erik J., Evans, William E.
Publicado no PLoS Comput Biol (2016)

Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia

Por Karol, Seth E., Larsen, Eric, Cheng, Cheng, Cao, Xueyuan, Yang, Wenjian, Ramsey, Laura B., Fernandez, Christian A., McCorkle, Joseph R., Paugh, Steven W., Autry, Robert J., Lopez-Lopez, Elixabet, Diouf, Barthelemy, Jeha, Sima, Pui, Ching-Hon, Raetz, Elizabeth A., Winick, Naomi J., Carroll, William L., Hunger, Stephen P., Loh, Mignon L., Devidas, Meenakshi, Evans, William E., Yang, Jun J., Relling, Mary V.
Publicado no Leukemia (2017)

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia

Por Diouf, Barthelemy, Crews, Kristine R., Lew, Glen, Pei, Deqing, Cheng, Cheng, Bao, Ju, Zheng, Jie J., Yang, Wenjian, Fan, Yiping, Wheeler, Heather E., Wing, Claudia, Delaney, Shannon M., Komatsu, Masaaki, Paugh, Steven W., McCorkle, Joseph Robert, Lu, Xiaomin, Winick, Naomi J., Carroll, William L., Loh, Mignon L., Hunger, Stephen P., Devidas, Meenakshi, Pui, Ching-Hon, Dolan, M. Eileen, Relling, Mary V., Evans, William E.
Publicado no JAMA (2015)

NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells

Por Paugh, Steven W., Bonten, Erik J., Savic, Daniel, Ramsey, Laura B., Thierfelder, William E., Gurung, Prajwal, Malireddi, R. K. Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R., Laudermilk, Lucas T., Panetta, John C., McCorkle, J. Robert, Fan, Yiping, Crews, Kristine R., Stocco, Gabriele, Wilkinson, Mark R., Ferreira, Antonio M., Cheng, Cheng, Yang, Wenjian, Karol, Seth E., Fernandez, Christian A., Diouf, Barthelemy, Smith, Colton, Hicks, J. Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J., Holmfeldt, Linda, Mullighan, Charles G., den Boer, Monique L., Pieters, Rob, Jeha, Sima, Dunwell, Thomas L., Latif, Farida, Bhojwani, Deepa, Carroll, William L., Pui, Ching-Hon, Myers, Richard M., Guy, R. Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V., Evans, William E.
Publicado no Nat Genet (2015)