Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates myriad important cellular processes, including growth, survival, cytoskeleton rearrangements, motility, and immunity. Here we report that treatment of Jurkat and U937 leukemia cells with the pan-sphingosine kinase (SphK) inhibitor N,N...

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Detalhes bibliográficos
Main Authors: Gude, David R., Alvarez, Sergio E., Paugh, Steven W., Mitra, Poulami, Yu, JiaDe, Griffiths, Rachael, Barbour, Suzanne E., Milstien, Sheldon, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493451/
https://ncbi.nlm.nih.gov/pubmed/18362204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-107169
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