Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal. We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for...

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Opis bibliograficzny
Główni autorzy: Jones, Courtney L., Bhatla, Teena, Blum, Roy, Wang, Jinhua, Paugh, Steven W., Wen, Xin, Bourgeois, Wallace, Bitterman, Danielle S., Raetz, Elizabeth A., Morrison, Debra J., Teachey, David T., Evans, William E., Garabedian, Michael J., Carroll, William L.
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2014
Hasła przedmiotowe:
Molecular Bases of Disease
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110265/
https://ncbi.nlm.nih.gov/pubmed/24895125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569889
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