Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal. We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for...

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Библиографические подробности
Главные авторы: Jones, Courtney L., Bhatla, Teena, Blum, Roy, Wang, Jinhua, Paugh, Steven W., Wen, Xin, Bourgeois, Wallace, Bitterman, Danielle S., Raetz, Elizabeth A., Morrison, Debra J., Teachey, David T., Evans, William E., Garabedian, Michael J., Carroll, William L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110265/
https://ncbi.nlm.nih.gov/pubmed/24895125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569889
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