Ikaros Deletions in BCR-ABL-negative Childhood Acute Lymphoblastic Leukemia Are Associated with a Distinct Gene Expression Signature but Do Not Result in Intrinsic Chemoresistance

BACKGROUND: Ikaros, the product of IKZF1, is a regulator of lymphoid development and polymorphisms in the gene have been associated with the childhood acute lymphoblastic leukemia (ALL). Additionally, IKZF1 deletions and mutations identify high risk biological subsets of ALL [1, 2]. PROCEDURE: To di...

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Bibliographic Details
Main Authors: Vitanza, Nicholas A., Zaky, Wafik, Blum, Roy, Meyer, Julia A., Wang, Jinhua, Bhatla, Teena, Morrison, Debra J., Raetz, Elizabeth A., Carroll, William L.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217284/
https://ncbi.nlm.nih.gov/pubmed/24976218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25119
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