Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal. We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for...

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Bibliografiske detaljer
Main Authors: Jones, Courtney L., Bhatla, Teena, Blum, Roy, Wang, Jinhua, Paugh, Steven W., Wen, Xin, Bourgeois, Wallace, Bitterman, Danielle S., Raetz, Elizabeth A., Morrison, Debra J., Teachey, David T., Evans, William E., Garabedian, Michael J., Carroll, William L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110265/
https://ncbi.nlm.nih.gov/pubmed/24895125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569889
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