Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal. We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for...

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Detalhes bibliográficos
Main Authors: Jones, Courtney L., Bhatla, Teena, Blum, Roy, Wang, Jinhua, Paugh, Steven W., Wen, Xin, Bourgeois, Wallace, Bitterman, Danielle S., Raetz, Elizabeth A., Morrison, Debra J., Teachey, David T., Evans, William E., Garabedian, Michael J., Carroll, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110265/
https://ncbi.nlm.nih.gov/pubmed/24895125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569889
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