PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

Treatment-related toxicity can be life-threatening and is the primary cause of interruption or discontinuation of chemotherapy for acute lymphoblastic leukemia (ALL), leading to an increased risk of relapse. Mercaptopurine is an essential component of continuation therapy in all ALL treatment protoc...

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Главные авторы: Stocco, Gabriele, Yang, Wenjian, Crews, Kristine R., Thierfelder, William E., Decorti, Giuliana, Londero, Margherita, Franca, Raffaella, Rabusin, Marco, Valsecchi, Maria Grazia, Pei, Deqing, Cheng, Cheng, Paugh, Steven W., Ramsey, Laura B., Diouf, Barthelemy, McCorkle, Joseph Robert, Jones, Terreia S., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Association Studies Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471396/
https://ncbi.nlm.nih.gov/pubmed/22846425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds302
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