PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

Treatment-related toxicity can be life-threatening and is the primary cause of interruption or discontinuation of chemotherapy for acute lymphoblastic leukemia (ALL), leading to an increased risk of relapse. Mercaptopurine is an essential component of continuation therapy in all ALL treatment protoc...

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Detalhes bibliográficos
Main Authors: Stocco, Gabriele, Yang, Wenjian, Crews, Kristine R., Thierfelder, William E., Decorti, Giuliana, Londero, Margherita, Franca, Raffaella, Rabusin, Marco, Valsecchi, Maria Grazia, Pei, Deqing, Cheng, Cheng, Paugh, Steven W., Ramsey, Laura B., Diouf, Barthelemy, McCorkle, Joseph Robert, Jones, Terreia S., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471396/
https://ncbi.nlm.nih.gov/pubmed/22846425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds302
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