Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

PURPOSE: Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL). We performed a genome-wide association study (GWAS) to identify comprehensively the genetic basis of MP intolerance in children with ALL. PATIENTS AND METHODS: The discovery GWAS and replication...

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Bibliografiske detaljer
Udgivet i:J Clin Oncol
Main Authors: Yang, Jun J., Landier, Wendy, Yang, Wenjian, Liu, Chengcheng, Hageman, Lindsey, Cheng, Cheng, Pei, Deqing, Chen, Yanjun, Crews, Kristine R., Kornegay, Nancy, Wong, F. Lennie, Evans, William E., Pui, Ching-Hon, Bhatia, Smita, Relling, Mary V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375304/
https://ncbi.nlm.nih.gov/pubmed/25624441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.59.4671
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