Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

BACKGROUND: 6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particularly life-threatening myelosuppression, due to genetic polymorphisms in enzymes t...

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Udgivet i:BMC Cancer
Main Authors: Zhou, Hong, Li, Lei, Yang, Peng, Yang, Lin, Zheng, Jin E., Zhou, Ying, Han, Yong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932771/
https://ncbi.nlm.nih.gov/pubmed/29720126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4398-2
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