Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia

BACKGROUND: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used as antileukemic medications in the maintenanc...

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Detalhes bibliográficos
Publicado no:J Med Biochem
Main Authors: Milosevic, Goran, Kotur, Nikola, Krstovski, Nada, Lazic, Jelena, Zukic, Branka, Stankovic, Biljana, Janic, Dragana, Katsila, Theodora, Patrinos, George P., Pavlovic, Sonja, Dokmanovic, Lidija
Formato: Artigo
Idioma:Inglês
Publicado em: Sciendo 2018
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298470/
https://ncbi.nlm.nih.gov/pubmed/30598629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/jomb-2017-0060
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