Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment

Methotrexate (MTX) is one of the staples of pediatric acute lymphoblastic leukemia (ALL) treatment. MTX targets the folate metabolic pathway (FMP). Abnormal function of the enzymes in FMP, due to genetic aberrations, leads to adverse drug reactions. The aim of this study was to investigate variants...

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Bibliografiske detaljer
Udgivet i:Genes (Basel)
Main Authors: Kotur, Nikola, Lazic, Jelena, Ristivojevic, Bojan, Stankovic, Biljana, Gasic, Vladimir, Dokmanovic, Lidija, Krstovski, Nada, Milosevic, Goran, Janic, Dragana, Zukic, Branka, Pavlovic, Sonja
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7230684/
https://ncbi.nlm.nih.gov/pubmed/32344632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11040468
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