Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment

To elucidate interpatient variability in thioguanine nucleotide (TGN) concentrations in acute lymphoblastic leukemia (ALL) cells, we determined the TGN concentrations in leukemic blasts from 82 children with newly diagnosed ALL after intravenous administration of mercaptopurine (MP). Patients treate...

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Détails bibliographiques
Auteurs principaux: Zaza, Gianluigi, Cheok, Meyling, Yang, Wenjian, Panetta, John C., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2005
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895216/
https://ncbi.nlm.nih.gov/pubmed/15905191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0143
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