PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

Treatment-related toxicity can be life-threatening and is the primary cause of interruption or discontinuation of chemotherapy for acute lymphoblastic leukemia (ALL), leading to an increased risk of relapse. Mercaptopurine is an essential component of continuation therapy in all ALL treatment protoc...

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Autori principali: Stocco, Gabriele, Yang, Wenjian, Crews, Kristine R., Thierfelder, William E., Decorti, Giuliana, Londero, Margherita, Franca, Raffaella, Rabusin, Marco, Valsecchi, Maria Grazia, Pei, Deqing, Cheng, Cheng, Paugh, Steven W., Ramsey, Laura B., Diouf, Barthelemy, McCorkle, Joseph Robert, Jones, Terreia S., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Association Studies Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471396/
https://ncbi.nlm.nih.gov/pubmed/22846425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds302
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