Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity

PURPOSE: Mercaptopurine plays a pivotal role in treatment of acute lymphoblastic leukemia (ALL) and autoimmune diseases, and inter-individual variability in mercaptopurine tolerance can influence treatment outcome. Thiopurine methyltransferase (TPMT) and multi-drug resistant Protein 4 4(MRP4) have b...

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Udgivet i:Cancer Chemother Pharmacol
Main Authors: Liu, Chengcheng, Janke, Laura J., Yang, Jun J., Evans, William E., Schuetz, John D, Relling, Mary V.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628515/
https://ncbi.nlm.nih.gov/pubmed/28623449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3361-2
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