Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity

PURPOSE: Mercaptopurine plays a pivotal role in treatment of acute lymphoblastic leukemia (ALL) and autoimmune diseases, and inter-individual variability in mercaptopurine tolerance can influence treatment outcome. Thiopurine methyltransferase (TPMT) and multi-drug resistant Protein 4 4(MRP4) have b...

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Bibliografiset tiedot
Julkaisussa:Cancer Chemother Pharmacol
Päätekijät: Liu, Chengcheng, Janke, Laura J., Yang, Jun J., Evans, William E., Schuetz, John D, Relling, Mary V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628515/
https://ncbi.nlm.nih.gov/pubmed/28623449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3361-2
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