Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness in a Murine Model

Thiopurines are used for many cancers, including acute lymphoblastic leukemia (ALL). Patients with an inherited host defect in thiopurine methyltransferase (TPMT) are at high risk for life-threatening toxicity if treated with conventional dosages, but the impact on antileukemic efficacy is less clea...

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Autors principals: Ramsey, Laura B., Janke, Laura J., Edick, Mathew J., Cheng, Cheng, Williams, Richard T., Sherr, Charles J., Evans, William E., Relling, Mary V.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019208/
https://ncbi.nlm.nih.gov/pubmed/24710003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000044
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