Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

Thiopurine methyltransferase (TPM T) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT...

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Main Authors: Relling, MV, Gardner, EE, Sandborn, WJ, Schmiegelow, K, Pui, C-H, Yee, SW, Stein, CM, Carrillo, M, Evans, WE, Klein, TE
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098761/
https://ncbi.nlm.nih.gov/pubmed/21270794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.320
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