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Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity

Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine. Erythrocyte (RBC) TPMT activity was measured in blood samples from 298 randomly selected subjects. Of the subjects, 88.6% were included in a subgroup with high e...

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Bibliografiska uppgifter
Huvudupphovsmän: Weinshilboum, Richard M., Sladek, Susan L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1980
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1686086/
https://ncbi.nlm.nih.gov/pubmed/7191632
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