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Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation
OBJECTIVE: Thiopurine S-methyltransferase *3A is degraded much more rapidly than is the “wild type” enzyme through a ubiquitin-proteasome dependent process. It also forms aggresomes, suggesting a possible dynamic balance between degradation and aggregation. We set out to identify genes encoding prot...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583164/ https://ncbi.nlm.nih.gov/pubmed/18820593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328313e03f |
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