Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

par Hafezi, Shirin, Rahmani, Mohamed
Publié dans Cancers (Basel) (2021)

Coordinate PI3K pathway and Bcl-2 family disruption in AML

par Bose, Prithviraj, Rahmani, Mohamed, Grant, Steven
Publié 2012

Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage,...

par Dai, Yun, Rahmani, Mohamed, Dent, Paul, Grant, Steven
Publié 2005

2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process

par Gao, Ning, Rahmani, Mohamed, Dent, Paul, Grant, Steven
Publié 2005

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechani...

par Dasmahapatra, Girija, Rahmani, Mohamed, Dent, Paul, Grant, Steven
Publié 2006

Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML

par Vachhani, Pankit, Bose, Prithviraj, Rahmani, Mohamed, Grant, Steven
Publié 2014

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress

par Gao, Ning, Rahmani, Mohamed, Shi, Xianglin, Dent, Paul, Grant, Steven
Publié 2006

MEK1/2 inhibitors sensitize Bcr/Abl(+) human leukemia cells to the dual Abl/Src inhibitor BMS-354/825

par Nguyen, Tri K., Rahmani, Mohamed, Harada, Hisashi, Dent, Paul, Grant, Steven
Publié 2007

On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments

par Toor, Amir A., Toor, Abdullah A., Rahmani, Mohamed, Manjili, Masoud H.
Publié dans J R Soc Interface (2016)

Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

par Martin, Aditi Pandya, Mitchell, clint, Rahmani, Mohamed, Nephew, Kenneth P., Grant, Steven, Dent, Paul
Publié 2009

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

par Rahmani, Mohamed, Aust, Mandy Mayo, Attkisson, Elisa, Williams, David C., Ferreira-Gonzalez, Andrea, Grant, Steven
Publié 2012

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism

par Rahmani, Mohamed, Aust, Mandy Mayo, Attkisson, Elisa, Williams, David C., Ferreira-Gonzalez, Andrea, Grant, Steven
Publié 2012

PI3K/mTOR INHIBITION MARKEDLY POTENTIATES HDAC INHIBITOR ACTIVITY IN NHL CELLS THROUGH BIM- and MCL-1-DEPENDENT MECHANISMS IN VITRO AND IN VIVO

par Rahmani, Mohamed, Aust, Mandy Mayo, Benson, Elisa C, Wallace, LaShanale, Friedberg, Jonathan, Grant, Steven
Publié 2014

Systems Immunology Analysis Reveals an Immunomodulatory Effect of Snail-p53 Binding on Neutrophil- and T Cell-Mediated Immunity in KRAS Mutant Non-Small Cell Lung Cancer

par Hammoudeh, Sarah Musa, Venkatachalam, Thenmozhi, Ansari, Abdul Wahid, Bendardaf, Riyad, Hamid, Qutayba, Rahmani, Mohamed, Hamoudi, Rifat
Publié dans Front Immunol (2020)

Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

par Dasmahapatra, Girija, Lembersky, Dmitry, Rahmani, Mohamed, Kramer, Lora, Friedberg, Jonathan, Fisher, Richard I., Dent, Paul, Grant, Steven
Publié 2009

The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress

par Rahmani, Mohamed, Davis, Eric Maynard, Crabtree, Timothy Ryan, Habibi, Joseph Reza, Nguyen, Tri K., Dent, Paul, Grant, Steven
Publié 2007

Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

par Nguyen, Tri, Parker, Rebecca, Hawkins, Elisa, Holkova, Beata, Yazbeck, Victor, Kolluri, Akhil, Kmieciak, Maciej, Rahmani, Mohamed, Grant, Steven
Publié dans Oncotarget (2017)

Correction: Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin’s lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

par Nguyen, Tri, Parker, Rebecca, Hawkins, Elisa, Holkova, Beata, Yazbeck, Victor, Kolluri, Akhil, Kmieciak, Maciej, Rahmani, Mohamed, Grant, Steven
Publié dans Oncotarget (2019)

Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

par Hammoudeh, Sarah Musa, Hammoudeh, Arabella Musa, Bhamidimarri, Poorna Manasa, Mahboub, Bassam, Halwani, Rabih, Hamid, Qutayba, Rahmani, Mohamed, Hamoudi, Rifat
Publié dans World J Gastroenterol (2021)

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

par Rahmani, Mohamed, Anderson, Anh, Habibi, Joseph Reza, Crabtree, Timothy Ryan, Mayo, Mandy, Harada, Hisashi, Ferreira-Gonzalez, Andrea, Dent, Paul, Grant, Steven
Publié 2009