Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1 expression. We examined whether inhibition of BCL-2 family function could restore Lapatinib toxicity in Lapatinib adapted tumor cells and enhance Lapatinib toxicity in naive...

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Hlavní autoři: Martin, Aditi Pandya, Mitchell, clint, Rahmani, Mohamed, Nephew, Kenneth P., Grant, Steven, Dent, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887451/
https://ncbi.nlm.nih.gov/pubmed/19823038
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