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Obatoclax and Lapatinib Interact to Induce Toxic Autophagy through NOXA
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor lapatinib could be overcome by the B cell CLL/lymphoma-2 (BCL-2) family antagonist obatoclax (GX15-070). Coadministration of lapatinib with obatoclax caused synergistic cell killing by eliciting autophagic cell death that was depend...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3310419/ https://ncbi.nlm.nih.gov/pubmed/22219388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076851 |
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