OSU-03012 interacts with lapatinib to kill brain cancer cells

We have further defined mechanism(s) by which the drug OSU-03012 (OSU) kills brain cancer cells. OSU toxicity was enhanced by the HSP90 inhibitor 17-N-Allylamino-17-demethoxygeldanamycin (17AAG) that correlated with reduced expression of ERBB1 and ERBB2. Inhibition of the extrinsic apoptosis pathway...

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Autori principali: Booth, Laurence, Cruickshanks, Nichola, Ridder, Thomas, Chen, Ching-Shih, Grant, Steven, Dent, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542242/
https://ncbi.nlm.nih.gov/pubmed/22990204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22275
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