PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

The present studies examined viability and DNA damage levels in mammary carcinoma cells following PARP1 and CHK1 inhibitor drug combination exposure. PARP1 inhibitors [AZD2281 ; ABT888 ; NU1025 ; AG014699] interacted with CHK1 inhibitors [UCN-01 ; AZD7762 ; LY2603618] to kill mammary carcinoma cells...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Booth, Laurence, Cruickshanks, Nichola, Ridder, Thomas, Dai, Yun, Grant, Steven, Dent, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2013
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672190/
https://ncbi.nlm.nih.gov/pubmed/23917378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.24424
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