PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

The present studies examined viability and DNA damage levels in mammary carcinoma cells following PARP1 and CHK1 inhibitor drug combination exposure. PARP1 inhibitors [AZD2281 ; ABT888 ; NU1025 ; AG014699] interacted with CHK1 inhibitors [UCN-01 ; AZD7762 ; LY2603618] to kill mammary carcinoma cells...

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Bibliografiske detaljer
Main Authors: Booth, Laurence, Cruickshanks, Nichola, Ridder, Thomas, Dai, Yun, Grant, Steven, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672190/
https://ncbi.nlm.nih.gov/pubmed/23917378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.24424
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