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PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells
The present studies examined viability and DNA damage levels in mammary carcinoma cells following PARP1 and CHK1 inhibitor drug combination exposure. PARP1 inhibitors [AZD2281 ; ABT888 ; NU1025 ; AG014699] interacted with CHK1 inhibitors [UCN-01 ; AZD7762 ; LY2603618] to kill mammary carcinoma cells...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672190/ https://ncbi.nlm.nih.gov/pubmed/23917378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.24424 |
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