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PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

The present studies examined viability and DNA damage levels in mammary carcinoma cells following PARP1 and CHK1 inhibitor drug combination exposure. PARP1 inhibitors [AZD2281 ; ABT888 ; NU1025 ; AG014699] interacted with CHK1 inhibitors [UCN-01 ; AZD7762 ; LY2603618] to kill mammary carcinoma cells...

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Bibliografische gegevens
Hoofdauteurs: Booth, Laurence, Cruickshanks, Nichola, Ridder, Thomas, Dai, Yun, Grant, Steven, Dent, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672190/
https://ncbi.nlm.nih.gov/pubmed/23917378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.24424
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