Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

Lignende værker

• Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression, decreased BAK activation, and not by ERBB receptor mutation
  af: Martin, Aditi Pandya, et al.
  Udgivet: (2008)
• BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
  af: Martin, Aditi Pandya, et al.
  Udgivet: (2009)
• Obatoclax and Lapatinib Interact to Induce Toxic Autophagy through NOXA
  af: Tang, Yong, et al.
  Udgivet: (2012)
• Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo
  af: Mitchell, Clint, et al.
  Udgivet: (2010)
• Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
  af: Park, Margaret A., et al.
  Udgivet: (2008)