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Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo

The present studies have examined approaches to suppress MCL-1 function in breast cancer cells, as a means to promote tumor cell death. Treatment of breast cancer cells with CDK inhibitors (flavopiridol; roscovitine) enhanced the lethality of the ERBB1 inhibitor lapatinib in a synergistic fashion. C...

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書誌詳細
主要な著者: Mitchell, Clint, Yacoub, Adly, Hamed, Hossein, Martin, Aditi Pandya, Bareford, M Danielle, Eulitt, Patrick, Yang, Chen, Nephew, Kenneth P, Dent, Paul
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040858/
https://ncbi.nlm.nih.gov/pubmed/20855960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.9.13273
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