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Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo
The present studies have examined approaches to suppress MCL-1 function in breast cancer cells, as a means to promote tumor cell death. Treatment of breast cancer cells with CDK inhibitors (flavopiridol; roscovitine) enhanced the lethality of the ERBB1 inhibitor lapatinib in a synergistic fashion. C...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3040858/ https://ncbi.nlm.nih.gov/pubmed/20855960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.9.13273 |
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