Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells

Prior studies have demonstrated that inhibition of CHK1 can promote the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and phosphorylation of histone H2AX and that inhibition of poly(ADP-ribose) polymerase 1 (PARP1) can affect growth factor-induced ERK1/2 activation. The prese...

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Bibliographic Details
Main Authors: Mitchell, Clint, Park, Margaret, Eulitt, Patrick, Yang, Chen, Yacoub, Adly, Dent, Paul
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981366/
https://ncbi.nlm.nih.gov/pubmed/20696794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067199
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