Sorafenib enhances pemetrexed cytotoxicity through an autophagy -dependent mechanism in cancer cells

Pemetrexed (ALIMTA) is a folate anti-metabolite that has been approved for the treatment of non-small cell lung cancer, and has been shown to stimulate autophagy. In the present study, we sought to further understand the role of autophagy in the response to pemetrexed and to test if combination ther...

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Main Authors: Bareford, M. Danielle, Park, Margaret A., Yacoub, Adly, Hamed, Hossein A., Tang, Yong, Cruickshanks, Nichola, Eulitt, Patrick, Hubbard, Nisan, Tye, Gary, Burow, Matthew E., Fisher, Paul B., Moran, Richard G., Nephew, Kenneth P., Grant, Steven, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139015/
https://ncbi.nlm.nih.gov/pubmed/21622715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0898
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