Sorafenib enhances pemetrexed cytotoxicity through an autophagy -dependent mechanism in cancer cells

Pemetrexed (ALIMTA) is a folate anti-metabolite that has been approved for the treatment of non-small cell lung cancer, and has been shown to stimulate autophagy. In the present study, we sought to further understand the role of autophagy in the response to pemetrexed and to test if combination ther...

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Hauptverfasser: Bareford, M. Danielle, Park, Margaret A., Yacoub, Adly, Hamed, Hossein A., Tang, Yong, Cruickshanks, Nichola, Eulitt, Patrick, Hubbard, Nisan, Tye, Gary, Burow, Matthew E., Fisher, Paul B., Moran, Richard G., Nephew, Kenneth P., Grant, Steven, Dent, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139015/
https://ncbi.nlm.nih.gov/pubmed/21622715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0898
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