Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

Mechanisms underlying interactions between the proteasome inhibitor bortezomib and small molecule Bcl-2 antagonists were examined in GC- and ABC-type human DLBCL (diffuse lymphocytic B-cell lymphoma) cells. Concomitant or sequential exposure to non- or minimally toxic concentrations of bortezomib or...

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Detalhes bibliográficos
Main Authors: Dasmahapatra, Girija, Lembersky, Dmitry, Rahmani, Mohamed, Kramer, Lora, Friedberg, Jonathan, Fisher, Richard I., Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902989/
https://ncbi.nlm.nih.gov/pubmed/19270531
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