A clickable psoralen to directly quantify DNA interstrand crosslinking and repair

Por Evison, Benjamin J., Actis, Marcelo L., Fujii, Naoaki
Publicado no Bioorg Med Chem (2016)

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair

Por Fujii, Naoaki, Evison, Benjamin J., Actis, Marcelo L., Inoue, Akira
Publicado no Bioorg Med Chem (2015)

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

Por Evison, Benjamin J., Actis, Marcelo L., Wu, Zhexiang, Shao, Youming, Heath, Richard J., Yang, Lei, Fujii, Naoaki
Publicado no Bioorg Med Chem (2014)

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

Por Vanarotti, Murugendra, Evison, Benjamin J., Actis, Marcelo L., Inoue, Akira, McDonald, Ezelle T., Shao, Youming, Heath, Richard J., Fujii, Naoaki
Publicado no Bioorg Med Chem (2018)

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensi...

Por Inoue, Akira, Kikuchi, Sotaro, Hishiki, Asami, Shao, Youming, Heath, Richard, Evison, Benjamin J., Actis, Marcelo, Canman, Christine E., Hashimoto, Hiroshi, Fujii, Naoaki
Publicado em 2014

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

Por Actis, Marcelo L., Ambaye, Nigus D., Evison, Benjamin J., Shao, Youming, Vanarotti, Murugendra, Inoue, Akira, McDonald, Ezelle T., Kikuchi, Sotaro, Heath, Richard, Hara, Kodai, Hashimoto, Hiroshi, Fujii, Naoaki
Publicado no Bioorg Med Chem (2016)

Capturing the direct binding of CFTR correctors to CFTR using click chemistry

Por Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Actis, Marcelo, Yarlagadda, Sunitha, Arora, Kavisha, Woodroofe, Koryse, Clancy, John P., Lin, Songbai, Ziady, Assem G., Frizzell, Raymond, Fujii, Naoaki, Naren, Anjaparavanda P.
Publicado no Chembiochem (2015)

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Por Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, MacDonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A
Publicado em 2013

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Por Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Qiao, Renping, Grace, Christy R. R., Yamaguchi, Masaya, Weissmann, Florian, Frye, Jeremiah J., Dube, Prakash, Ei Cho, Shein, Actis, Marcelo L., Rodrigues, Patrick, Fujii, Naoaki, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Publicado no Proc Natl Acad Sci U S A (2015)

NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells

Por Paugh, Steven W., Bonten, Erik J., Savic, Daniel, Ramsey, Laura B., Thierfelder, William E., Gurung, Prajwal, Malireddi, R. K. Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R., Laudermilk, Lucas T., Panetta, John C., McCorkle, J. Robert, Fan, Yiping, Crews, Kristine R., Stocco, Gabriele, Wilkinson, Mark R., Ferreira, Antonio M., Cheng, Cheng, Yang, Wenjian, Karol, Seth E., Fernandez, Christian A., Diouf, Barthelemy, Smith, Colton, Hicks, J. Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J., Holmfeldt, Linda, Mullighan, Charles G., den Boer, Monique L., Pieters, Rob, Jeha, Sima, Dunwell, Thomas L., Latif, Farida, Bhojwani, Deepa, Carroll, William L., Pui, Ching-Hon, Myers, Richard M., Guy, R. Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V., Evans, William E.
Publicado no Nat Genet (2015)