A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin

Small molecule inhibitors of proliferating cell nuclear antigen (PCNA)/PCNA interacting protein box (PIP-Box) interactions, including T2 amino alcohol (T2AA), inhibit translesion DNA synthesis. The crystal structure of PCNA in complex with T2AA revealed that T2AA bound to the surface adjacent to the...

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Bibliografiset tiedot
Päätekijät: Inoue, Akira, Kikuchi, Sotaro, Hishiki, Asami, Shao, Youming, Heath, Richard, Evison, Benjamin J., Actis, Marcelo, Canman, Christine E., Hashimoto, Hiroshi, Fujii, Naoaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
DNA and Chromosomes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945371/
https://ncbi.nlm.nih.gov/pubmed/24474685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520429
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