Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

Por Mahindroo, Neeraj, Punchihewa, Chandanamali, Fujii, Naoaki
Publicado em 2009

Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas

Por Zhang, Weiqiang, Fujii, Naoaki, Naren, Anjaparavanda P
Publicado em 2012

A clickable psoralen to directly quantify DNA interstrand crosslinking and repair

Por Evison, Benjamin J., Actis, Marcelo L., Fujii, Naoaki
Publicado no Bioorg Med Chem (2016)

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair

Por Fujii, Naoaki, Evison, Benjamin J., Actis, Marcelo L., Inoue, Akira
Publicado no Bioorg Med Chem (2015)

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

Por Punchihewa, Chandanamali, Ferreira, Antonio M, Cassell, Robert, Rodrigues, Patrick, Fujii, Naoaki
Publicado em 2009

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

Por Punchihewa, Chandanamali, Ferreira, Antonio M, Cassell, Robert, Rodrigues, Patrick, Fujii, Naoaki
Publicado em 2009

Amide Conjugates of Ketoprofen and Indole as Inhibitors of Gli1-Mediated Transcription in the Hedgehog Pathway

Por Mahindroo, Neeraj, Connelly, Michele C., Punchihewa, Chandanamali, Yang, Lei, Yan, Bing, Fujii, Naoaki
Publicado em 2010

Structure-Activity Relationships and Cancer-Cell Selective Toxicity of Novel Inhibitors of Glioma-Associated Oncogene Homolog 1 (Gli1)-Mediated Transcription

Por Mahindroo, Neeraj, Connelly, Michele C., Punchihewa, Chandanamali, Kimura, Hiromichi, Smeltzer, Matthew P., Wu, Song, Fujii, Naoaki
Publicado em 2009

Functional regulation of CFTR-containing macromolecular complexes: a small-molecule inhibitor approach

Por ZHANG, Weiqiang, PENMATSA, Himabindu, REN, Aixia, PUNCHIHEWA, Chandanamali, LEMOFF, Andrew, YAN, Bing, FUJII, Naoaki, NAREN, Anjaparavanda P.
Publicado em 2011

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

Por Evison, Benjamin J., Actis, Marcelo L., Wu, Zhexiang, Shao, Youming, Heath, Richard J., Yang, Lei, Fujii, Naoaki
Publicado no Bioorg Med Chem (2014)

Inhibition of Tax transformation activity using a small molecule targeting Tax/PDZ domain interactions

Por Blibek, Karim, Fujii, Naoaki, Legros, Sebastien, Boxus, Mathieu, Dewulf, Jean-François, Zimmermann, Pascale, Kettmann, Richard, Dequiedt, Franck, Twizere, Jean-Claude
Publicado em 2014

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

Por Vanarotti, Murugendra, Evison, Benjamin J., Actis, Marcelo L., Inoue, Akira, McDonald, Ezelle T., Shao, Youming, Heath, Richard J., Fujii, Naoaki
Publicado no Bioorg Med Chem (2018)

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensi...

Por Inoue, Akira, Kikuchi, Sotaro, Hishiki, Asami, Shao, Youming, Heath, Richard, Evison, Benjamin J., Actis, Marcelo, Canman, Christine E., Hashimoto, Hiroshi, Fujii, Naoaki
Publicado em 2014

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

Por Actis, Marcelo L., Ambaye, Nigus D., Evison, Benjamin J., Shao, Youming, Vanarotti, Murugendra, Inoue, Akira, McDonald, Ezelle T., Kikuchi, Sotaro, Heath, Richard, Hara, Kodai, Hashimoto, Hiroshi, Fujii, Naoaki
Publicado no Bioorg Med Chem (2016)

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

Por Punchihewa, Chandanamali, Inoue, Akira, Hishiki, Asami, Fujikawa, Yoshihiro, Connelly, Michele, Evison, Benjamin, Shao, Youming, Heath, Richard, Kuraoka, Isao, Rodrigues, Patrick, Hashimoto, Hiroshi, Kawanishi, Masanobu, Sato, Mamoru, Yagi, Takashi, Fujii, Naoaki
Publicado em 2012

Capturing the direct binding of CFTR correctors to CFTR using click chemistry

Por Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Actis, Marcelo, Yarlagadda, Sunitha, Arora, Kavisha, Woodroofe, Koryse, Clancy, John P., Lin, Songbai, Ziady, Assem G., Frizzell, Raymond, Fujii, Naoaki, Naren, Anjaparavanda P.
Publicado no Chembiochem (2015)

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Por Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, MacDonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A
Publicado em 2013

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Por Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Qiao, Renping, Grace, Christy R. R., Yamaguchi, Masaya, Weissmann, Florian, Frye, Jeremiah J., Dube, Prakash, Ei Cho, Shein, Actis, Marcelo L., Rodrigues, Patrick, Fujii, Naoaki, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Publicado no Proc Natl Acad Sci U S A (2015)

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via Wnt Signaling and Stabilization of Low Density Lipoprotein Receptor-related Proteins 5 and 6

Por Lai, Keane K.Y., Kweon, Soo-Mi, Chi, Feng, Hwang, Edward, Kabe, Yasuaki, Higashiyama, Reiichi, Qin, Lan, Yan, Rui, Wu, Raymond P., Fujii, Naoaki, French, Samuel, Xu, Jun, Wang, Jian-Ying, Murali, Ramanchadran, Mishra, Lopa, Lee, Ju-Seog, Ntambi, James M., Tsukamoto, Hidekazu
Publicado no Gastroenterology (2017)

Targeting Gli Transcription Activation by Small Molecule Suppresses Tumor Growth

Por Bosco-Clément, Geneviève, Zhang, Fang, Chen, Zhao, Zhou, Hai-Meng, Li, Hui, Mikami, Iwao, Hirata, Tomomi, Yagui-Beltran, Adam, Lui, Natalie, Do, Hanh T., Cheng, Tiffany, Tseng, Hsin-Hui, Choi, Helen, Fang, Li-Tai, Kim, Il-Jin, Yue, Dongsheng, Wang, Changli, Zheng, Qingfeng, Fujii, Naoaki, Mann, Michael, Jablons, David M., He, Biao
Publicado em 2013