Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

REV1 protein is a mutagenic DNA damage tolerance (DDT) mediator and encodes two ubiquitin-binding motifs (i.e., UBM1 and UBM2) that are essential for the DDT function. REV1 interacts with K164-monoubiquitinated PCNA (UbPCNA) in cells upon DNA-damaging stress. By using AlphaScreen assays to detect in...

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Publicado no:Bioorg Med Chem
Main Authors: Vanarotti, Murugendra, Evison, Benjamin J., Actis, Marcelo L., Inoue, Akira, McDonald, Ezelle T., Shao, Youming, Heath, Richard J., Fujii, Naoaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935547/
https://ncbi.nlm.nih.gov/pubmed/29598900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.028
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