EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells

Patients with gliomas expressing high levels of epidermal growth factor receptor (EGFR) and plasminogen activator inhibitor-1 (PAI-1) have a shorter overall survival prognosis. Moreover, EGF enhances PAI-1 expression in glioma cells. Although multiple known signaling cascades are activated by EGF in...

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Main Authors: Paugh, Barbara S., Paugh, Steven W., Bryan, Lauren, Kapitonov, Dmitri, Wilczynska, Katarzyna M., Gopalan, Sunita M., Rokita, Hanna, Milstien, Sheldon, Spiegel, Sarah, Kordula, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752832/
https://ncbi.nlm.nih.gov/pubmed/17855624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-8276com
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