A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E...

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Detalhes bibliográficos
Main Authors: Paugh, Steven W., Paugh, Barbara S., Rahmani, Mohamed, Kapitonov, Dmitri, Almenara, Jorge A., Kordula, Tomasz, Milstien, Sheldon, Adams, Jeffrey K., Zipkin, Robert E., Grant, Steven, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515133/
https://ncbi.nlm.nih.gov/pubmed/18511810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-138958
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