Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia

Using broad interrogation of clinically relevant ADME genes on the DMET platform, we identified a genetic variant in SLCO1B1 (rs2291075; c.597C>T), encoding the transporter OATP1B1, associated with event free (P=0.006, hazard ratio=1.74) and overall survival (P=0.012, hazard ratio=1.85) in childr...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Drenberg, Christina D., Paugh, Steven W., Pounds, Stanley B., Shi, Lei, Orwick, Shelley J., Li, Lie, Hu, Shuiying, Gibson, Alice A., Ribeiro, Raul C., Rubnitz, Jeffrey E., Evans, William E., Sparreboom, Alex, Baker, Sharyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898266/
https://ncbi.nlm.nih.gov/pubmed/26663398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.315
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