Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

PURPOSE: Many tyrosine kinase inhibitors (TKIs) undergo extensive hepatic metabolism, but mechanisms of their hepatocellular uptake remain poorly understood. We hypothesized that liver uptake of TKIs is mediated by the solute carriers OATP1B1 and OATP1B3. EXPERIMENTAL DESIGN: Transport of crizotinib...

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Hauptverfasser: Zimmerman, Eric I., Hu, Shuiying, Roberts, Justin L., Gibson, Alice A., Orwick, Shelley J., Li, Lie, Sparreboom, Alex, Baker, Sharyn D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602278/
https://ncbi.nlm.nih.gov/pubmed/23340295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3306
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