Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Recently, an efficient liver detoxification process dubbed ‘hepatocyte hopping’ was proposed based on findings with the endogenous compound, bilirubin glucuronide. According to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop via Abcc3 transporter-mediated eff...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Vasilyeva, Aksana, Durmus, Selvi, Li, Lie, Wagenaar, Els, Hu, Shuiying, Gibson, Alice A., Panetta, John C., Mani, Sridhar, Sparreboom, Alex, Baker, Sharyn D., Schinkel, Alfred H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490028/
https://ncbi.nlm.nih.gov/pubmed/25952649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0280
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