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Sorafenib Metabolism, Transport, and Enterohepatic Recycling: Physiologically Based Modeling and Simulation in Mice
PURPOSE: This study used uncertainty and sensitivity analysis to evaluate a physiologically based pharmacokinetic (PBPK) model of the complex mechanisms of sorafenib and its two main metabolites, sorafenib glucuronide and sorafenib N-oxide in mice. METHODS: A PBPK model for sorafenib and its two mai...
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| 出版年: | Cancer Chemother Pharmacol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4846505/ https://ncbi.nlm.nih.gov/pubmed/27053087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3018-6 |
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