Ontogeny and sorafenib metabolism

PURPOSE: To investigate the role of ontogeny in sorafenib metabolism to the equipotent active metabolite sorafenib N-oxide. EXPERIMENTAL DESIGN: Steady-state pharmacokinetic studies of sorafenib and metabolites were performed in thirty children and young adults (17 males; median age, 9.5 years) rece...

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Main Authors: Zimmerman, Eric I., Roberts, Justin L., Li, Lie, Finkelstein, David, Gibson, Alice, Chaudhry, Amarjit S., Schuetz, Erin G., Rubnitz, Jeffrey E., Inaba, Hiroto, Baker, Sharyn D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490489/
https://ncbi.nlm.nih.gov/pubmed/22927483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1967
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