OATP1B1 Polymorphism as a Determinant of Erythromycin Disposition

Previous studies have demonstrated that the pharmacokinetic profile of erythromycin, a probe for CYP3A4 activity, is affected by inhibitors or inducers of hepatic solute carriers. We hypothesized that these interactions are mediated by OATP1B1 (gene symbol, SLCO1B1), a polypeptide expressed on the b...

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Main Authors: Lancaster, CS, Bruun, GH, Peer, CJ, Mikkelsen, TS, Corydon, TJ, Gibson, AA, Hu, S, Orwick, SJ, Mathijssen, RHJ, Figg, WD, Baker, SD, Sparreboom, A
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478421/
https://ncbi.nlm.nih.gov/pubmed/22990751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.106
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